TALL CELL PAPILLARY THYROID-CANCER - INCIDENCE AND PROGNOSIS

BACKGROUND: The tall cell Variant (TCV) of papillary thyroid cancer is reported to have a poor prognosis. This study examines the incidence and end result of surgical treatment of TCV. METHODS: In this study, 2 40 thyroid cancers treated over a 23-year period at two hospital cente rs are reviewed. A total of 153 patients with papillary cancer were av ailable for follow-up. Ah microscopic slides were re-examined. RESULTS : Of the total 183 papillary cancers, 19 (10.4%) were TCV. The remaind er were usual papillary or other papillary cancer variants. Patient ag e, tumor size, lymph node and soft-tissue involvement, recurrence, and death rates were evaluated. Multivariate statistical analysis disclos ed that TCV histology, as well as age and tumor size, were significant predictors of recurrence. CONCLUSION: Despite a high rate of recurren ce in TCV cases over age 50 (6/9), there were no recurrent TCVs in cas es under age 50 (0/8). Pathologists and surgeons must develop an incre ased awarenenss of this entity and implications for more radical treat ment in the older age group.