Zp. Zhu et al., TUMOR-LOCALIZATION AND THERAPEUTIC POTENTIAL OF AN ANTITUMOR-ANTI-CD3HETEROCONJUGATE ANTIBODY IN HUMAN RENAL-CELL CARCINOMA XENOGRAFT MODELS, Cancer letters, 86(1), 1994, pp. 127-134
A heteroconjugate (HC) antibody, constructed with the monoclonal antib
ody (MoAB) Dal K29 to human renal cell carcinoma (RCC) and an anti-CD3
MoAb, could induce a very high level of lysis of human RCC cells when
incubated with human peripheral blood lymphocytes (PBL) in vitro (Ker
r et al., 1990, J. Immunol., 144, 4060-4067). We now report that this
HC antibody selectively localizes in RCC xenografts in nude mice and c
ould inhibit RCC in an ascites tumor xenograft model when administered
intraperitoneally together with PBL.