TUMOR-LOCALIZATION AND THERAPEUTIC POTENTIAL OF AN ANTITUMOR-ANTI-CD3HETEROCONJUGATE ANTIBODY IN HUMAN RENAL-CELL CARCINOMA XENOGRAFT MODELS

Authors
ZHU ZP GHOSE T LEE SHS FERNANDEZ LA KERR LA DONOHUE JH MCKEAN DJ
Citation
Zp. Zhu et al., TUMOR-LOCALIZATION AND THERAPEUTIC POTENTIAL OF AN ANTITUMOR-ANTI-CD3HETEROCONJUGATE ANTIBODY IN HUMAN RENAL-CELL CARCINOMA XENOGRAFT MODELS, Cancer letters, 86(1), 1994, pp. 127-134
Citations number
22
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
86
Issue
1
Year of publication
1994
Pages
127 - 134
Database
ISI
SICI code
0304-3835(1994)86:1<127:TATPOA>2.0.ZU;2-Z
Abstract
A heteroconjugate (HC) antibody, constructed with the monoclonal antib ody (MoAB) Dal K29 to human renal cell carcinoma (RCC) and an anti-CD3 MoAb, could induce a very high level of lysis of human RCC cells when incubated with human peripheral blood lymphocytes (PBL) in vitro (Ker r et al., 1990, J. Immunol., 144, 4060-4067). We now report that this HC antibody selectively localizes in RCC xenografts in nude mice and c ould inhibit RCC in an ascites tumor xenograft model when administered intraperitoneally together with PBL.