Fg. Rong et Ah. Soloway, SYNTHESIS OF 5-TETHERED CARBORANE-CONTAINING PYRIMIDINE NUCLEOSIDES AS POTENTIAL AGENTS FOR DNA INCORPORATION, Nucleosides & nucleotides, 13(9), 1994, pp. 2021-2034
Several 5-substituted-2'-deoxyuridines have been prepared in which the
carborane moiety is attached at the terminus of a flexible hydrocarbo
n chain containing an ester linkage. These boron moieties as the B-10
enriched compounds have potentiality for use in the treatment of cance
r by means of boron neutron capture therapy. A convenient synthetic ro
ute, in high yield, has been developed for the preparation of these 5-
tethered carborane-containing pyrimidine nucleosides.