SYNTHESIS OF 5-TETHERED CARBORANE-CONTAINING PYRIMIDINE NUCLEOSIDES AS POTENTIAL AGENTS FOR DNA INCORPORATION

Authors
RONG FG SOLOWAY AH
Citation
Fg. Rong et Ah. Soloway, SYNTHESIS OF 5-TETHERED CARBORANE-CONTAINING PYRIMIDINE NUCLEOSIDES AS POTENTIAL AGENTS FOR DNA INCORPORATION, Nucleosides & nucleotides, 13(9), 1994, pp. 2021-2034
Citations number
21
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
9
Year of publication
1994
Pages
2021 - 2034
Database
ISI
SICI code
0732-8311(1994)13:9<2021:SO5CPN>2.0.ZU;2-T
Abstract
Several 5-substituted-2'-deoxyuridines have been prepared in which the carborane moiety is attached at the terminus of a flexible hydrocarbo n chain containing an ester linkage. These boron moieties as the B-10 enriched compounds have potentiality for use in the treatment of cance r by means of boron neutron capture therapy. A convenient synthetic ro ute, in high yield, has been developed for the preparation of these 5- tethered carborane-containing pyrimidine nucleosides.