EFFECTS OF FEPRADINOL ON RAT ACUTE MODELS OF VASCULAR-PERMEABILITY AND LEUKOCYTE MIGRATION

The antiinflammatory compound fepradinol has been tested in several ex perimental models of acute inflammation in rats. On the increased vasc ular permeability in the skin, fepradinol (25 mg/kg p.o.) was the only compound that inhibited the inflammatory actions induced by the three chemical mediators injected (histamine, serotonin and bradykinin). On the carrageenin-induced pleurisy, fepradinol (100 mg/kg p.o.) was mor e potent than indomethacin (5 mg/kg p.o.) and similar to piroxicam (5 mg/kg p.o.) in reducing the exudate volume and preventing cell migrati on. On the zymosan-induced peritonitis, while the activity of indometh acin (10 mg/kg p.o.) and cyproheptadine was observed only 3 h after zy mosan challenge, the response of fepradinol developed within 30 min, s uggesting that fepradinol inhibits both the early and late phases of t he exudative response. These findings indicate that fepradinol may act on acute inflammation by reducing vascular permeability.