LACK OF STIMULATORY EFFECT OF 1,25(OH)(2)VITAMIN-D-3 ON BETA-ENDORPHIN AND CORTISOL SECRETION

The aim of the work was to investigate the effect of 1,25 (OH)(2) vita min D-3 on beta-endorphin and cortisol secretion in vivo. beta-Endorph in, cortisol, calcium and phosphate in blood were measured in ten heal thy unstressed volunteers before and after 4-day oral administration o f 1,25 (OH)(2) vitamin D-3 in doses of 3 mu g/d. The biological effect iveness of the treatment was proved by a significant increase of calce mia as compared with control values (2.71+/-0.03 vs 2.57+/-0.02 mmol/l , mean+/-SE, p<0.01) and phosphatemia (1.18+/-0.06 vs 0.89+/-0.01 mmol /l, p<0.01). beta-Endorphin after treatment was 39.1+/-9.2 (vs 42.7+/- 7.6) ng/l and cortisol 369+/-35 (vs 377+/-31) nmol/l. In conclusion, i n spite of the good compliance of the treatment, 1,25 (OH)(2)-vitamin D3 stimulates neither beta-endorphin nor cortisol secretion in healthy subjects.