ACTIVATION OF THE NO-CGMP SIGNALING PATHWAY DEPRESSES HIPPOCAMPAL SYNAPTIC TRANSMISSION THROUGH AN ADENOSINE RECEPTOR-DEPENDENT MECHANISM

Authors
BROOME MR COLLINGRIDGE GL IRVING AJ
Citation
Mr. Broome et al., ACTIVATION OF THE NO-CGMP SIGNALING PATHWAY DEPRESSES HIPPOCAMPAL SYNAPTIC TRANSMISSION THROUGH AN ADENOSINE RECEPTOR-DEPENDENT MECHANISM, Neuropharmacology, 33(11), 1994, pp. 1511-1513
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
33
Issue
11
Year of publication
1994
Pages
1511 - 1513
Database
ISI
SICI code
0028-3908(1994)33:11<1511:AOTNSP>2.0.ZU;2-L
Abstract
Activation of the NO-cGMP pathway or adenosine receptors depresses rev ersibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective Al receptor antagonist DPCPX, a convergence in th e mechanisms of action of the NO donor SNAP, the cGMP phosphodiesteras e inhibitor zaprinast and adenosine.