A REVIEW OF STUDIES OF THE ACTIVATION OF THE BLOOD-COAGULATION MECHANISM IN CHIMPANZEES (PAN-TROGLODYTES)

Authors
TENCATE H SCHENK BE BIEMOND BJ LEVI M VANDERPOLL T BULLER HR TENCATE JW
Citation
H. Tencate et al., A REVIEW OF STUDIES OF THE ACTIVATION OF THE BLOOD-COAGULATION MECHANISM IN CHIMPANZEES (PAN-TROGLODYTES), Journal of medical primatology, 23(5), 1994, pp. 280-284
Citations number
32
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
23
Issue
5
Year of publication
1994
Pages
280 - 284
Database
ISI
SICI code
0047-2565(1994)23:5<280:AROSOT>2.0.ZU;2-E
Abstract
This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoass ays that measure activation markers of blood coagulation in plasma. In fused factor VIIa activated both factors IX and X in vivo; this reacti on depended on the formation of the factor VIIa-tissue factor (TF) com plex. The infusion of endotoxin also led to assembly of the factor VII a-TF complex, enhancing fibrin formation. This process occurred throug h the intermediate action of specific cytokines.