BASIC STUDIES OF THE INFLUENCE OF BETA-CYCLODEXTRIN AND 2-HYDROXYPROPYL BETA-CYCLODEXTRIN ON THE PHOTOOXIDATION REACTION OF PHENOTHIAZINE IN INCLUSION COMPLEXES, USING FLUORESCENCE DETECTION

The photo-oxidation reaction of phenothiazine has been studied in the presence of beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclo dextrin (HP beta-CD). The influence of these organized media on the fo rmation of the oxidation photoproduct upon UV irradiation has been inv estigated. Phenothiazine forms an inclusion complex with the cyclodext rins. The stoichiometry and formation constant of the complex formed w ith 2-hydroxypropyl beta-CD have been calculated using the changes of the fluorescence emission signal and of the absorbance of the drug upo n inclusion. An increase of the fluorescence intensity of the photogen erated product is attained when it becomes included inside the cyclode xtrin cavity.