BASIC STUDIES OF THE INFLUENCE OF BETA-CYCLODEXTRIN AND 2-HYDROXYPROPYL BETA-CYCLODEXTRIN ON THE PHOTOOXIDATION REACTION OF PHENOTHIAZINE IN INCLUSION COMPLEXES, USING FLUORESCENCE DETECTION
Jj. Aaron et al., BASIC STUDIES OF THE INFLUENCE OF BETA-CYCLODEXTRIN AND 2-HYDROXYPROPYL BETA-CYCLODEXTRIN ON THE PHOTOOXIDATION REACTION OF PHENOTHIAZINE IN INCLUSION COMPLEXES, USING FLUORESCENCE DETECTION, Journal of inclusion phenomena and molecular recognition in chemistry, 18(1), 1994, pp. 69-79
The photo-oxidation reaction of phenothiazine has been studied in the
presence of beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclo
dextrin (HP beta-CD). The influence of these organized media on the fo
rmation of the oxidation photoproduct upon UV irradiation has been inv
estigated. Phenothiazine forms an inclusion complex with the cyclodext
rins. The stoichiometry and formation constant of the complex formed w
ith 2-hydroxypropyl beta-CD have been calculated using the changes of
the fluorescence emission signal and of the absorbance of the drug upo
n inclusion. An increase of the fluorescence intensity of the photogen
erated product is attained when it becomes included inside the cyclode
xtrin cavity.