1,4-NAPHTHOQUINONES .23. 2 3-HALOGENO-2/3 -NITROPHENYL-JUGLONE DERIVATIVES, SYNTHESIS AND CYTOTOXIC PROPERTIES/

Radical arylation of 1,4-naphthoquinones is possible by oxidative deca rboxylation of 2- and 4-nitrobenzoic acid. With 2- and 3-halogenojuglo ne derivatives the 4-nitrophenyl compounds 10-13 are prepared in good, the 2-nitrophenyl analogues 14-17 only in poor yields. - All compound s are inactive against the virus types HSV and HIV and their marked cy totoxicity in part depends on the substitution pattern. The 3-aryl and o-nitro derivatives are more active than their 2-aryl and p-nitro ana logues and the influence of the chloro or bromo substitution is only r emarkable in the case of 12/13.