THE IN-VITRO TRYPANOCIDAL ACTIVITY OF ORGANOTIN COMPOUNDS

A series of alkyl (aryl) thio organotin compounds were synthesized as potential trypanocidal drugs. These derivatives were prepared by the t reatment of alkyl (or aryl) tin chlorides or oxides with thiols. Compo unds were evaluated for trypanocidal activity using in vitro cultures of Trypanosoma equiperdum. Their efficiency for killing the parasites appeared to be under control of both the alkyl (or aryl) part of the m olecule and the thio moiety. Several of the synthesized compounds exhi bited a high in vitro levels of activity compared with the arsenic der ivatives used for chemotherapy.