INHIBITION OF PENICILLIN BIOSYNTHETIC-ENZYMES BY HALOGEN-DERIVATIVES OF PHENYLACETIC ACID

Authors
MARTINEZBLANCO H REGLERO A LUENGO JM
Citation
H. Martinezblanco et al., INHIBITION OF PENICILLIN BIOSYNTHETIC-ENZYMES BY HALOGEN-DERIVATIVES OF PHENYLACETIC ACID, Journal of industrial microbiology, 13(3), 1994, pp. 144-146
Citations number
13
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Journal of industrial microbiology → ACNP
ISSN journal
01694146
Volume
13
Issue
3
Year of publication
1994
Pages
144 - 146
Database
ISI
SICI code
0169-4146(1994)13:3<144:IOPBBH>2.0.ZU;2-9
Abstract
The effect of phenylacetic acid (PAA) and several analogs on the activ ity of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransfe rase (AT) from Penicillium chrysogenum Wis 54-1255 has been tested. Wh ereas the substitution on the ring of a hydrogen atom by hydroxy-, met hyl- or methoxy- groups did not cause any effect, the presence of halo gens (Cl or Br) at positions 3 and/or 4 of PAA strongly inhibited thes e two enzymes. The replacement of hydrogen atoms by fluorine in certai n positions also caused inhibition, but to a lesser extent.