CRYSTAL-STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT-LIVER

Authors
SU Y SKINNER MM XUONG NH MATTHEWS DA WHITELEY JM VARUGHESE KI
Citation
Y. Su et al., CRYSTAL-STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT-LIVER, Acta crystallographica. Section D, Biological crystallography, 50, 1994, pp. 884-888
Citations number
15
Categorie Soggetti
Crystallography,Biology,"Pharmacology & Pharmacy
Journal title
Acta crystallographica. Section D, Biological crystallography → ACNP
ISSN journal
09074449
Volume
50
Year of publication
1994
Part
6
Pages
884 - 888
Database
ISI
SICI code
0907-4449(1994)50:<884:COAMFO>2.0.ZU;2-4
Abstract
A binary complex of dihydropteridine reductase and NADH crystallizes i n the space group C2, with a = 222.2, b = 46.5, c = 95.3 Angstrom and beta = 101.1 degrees. There are two dimers in the asymmetric unit. The structure was solved by molecular-replacement techniques and refined with 2.6 Angstrom data to a crystallographic R factor of 16.8%. Each d imer has twofold non-crystallographic symmetry and the four individual monomers in the asymmetric unit have the same overall molecular confo rmation.