PHARMACOKINETICS OF BENDAZAC LYSINE IN 10 CHINESE YOUNG MEN

AIM: To compare the pharmacokinetics of domestic and imported tablets of bendazac lysine (BL). METHODS: A single oral dose of 500 mg BL of t his 2 kinds of tablets was given to 10 Chinese volunteers of Han natio nality in a randomized crossover study. Plasma levels were determined with HPLC-UV method. Data were analyzed automatically by using a CAPP program on microcomputer. RESULTS: The;plasma concentration-time curve was fitted to 2-compartment open model, and the major pharmacokinetic parameters of domestic and imported BL tablets were shown respectivel y as following: C-max 66 +/- 16 and 65 +/- 8 mg . L(-1); T-max 0.98 +/ - 0.22 and 0.98 +/- 0.21 h; T-1/2 beta 6.2 +/- 1.8 and 6.2 +/- 1.7 h; AUC 335 +/- 47 and 337 +/- 58 mg . h . L(-1). There was no significant difference between domestic and imported tablets. The bioavailability of the domestic vs that of the imported tablet was 99 +/- 12 %. The u nchanged BL in urine were about 5.4 % and 5.6 % respectively of the do sage in 24 h after a single oral dose. CONCLUSION: The two kinds of ta blets had the same biological effects.