EFFECTS OF TETRAHYDROPROTOBERBERINES ON DOPAMINE D-2 RECEPTORS IN VENTRAL TEGMENTAL AREA OF RAT

Authors
WANG LM ZHANG XX JIN GZ
Citation
Lm. Wang et al., EFFECTS OF TETRAHYDROPROTOBERBERINES ON DOPAMINE D-2 RECEPTORS IN VENTRAL TEGMENTAL AREA OF RAT, Zhongguo yaoli xuebao, 18(2), 1997, pp. 143-146
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
18
Issue
2
Year of publication
1997
Pages
143 - 146
Database
ISI
SICI code
0253-9756(1997)18:2<143:EOTODD>2.0.ZU;2-Y
Abstract
AIM: To compare the actions of tetrahydroprotoberberines (THPB) on dop a;nine (DA) D-2 receptors in the ventral tegmental area (VTA) of rat. METHODS: Extracellular single unit recording technique was used in iv gallamine-paralyzed rats. RESULTS: Eleven THPB analogs tested complete ly attenuated the apomorphine (Apo, 20 mu g . kg(-1))-induced inhibiti on on VTA DA cell firing activity. The OH group on C-2 at THPB was lin ked with the reversal of Apo-induced inhibition. Their reversal potenc ies (ED(50), mu g . L(-1)) for D-2 receptors were: THPB-143 (5.6) > SP D (8.5) > Iso (17.0) > THP (33) > THE (48) > THPB-18 (66) > THPB-1 (17 9) > THPB-19 (408) > THPI-126 (510) > THPB-104 (1019) > THPB-10 (4815) . CONCLUSION: Among these 11 THPB, the 2-hydroxyl-THPB (THPB-143) show ed the strongest antagonistic action on D-2 receptors.