LONG-TERM PRODUCTION AND DELIVERY OF HUMAN GROWTH-HORMONE IN-VIVO

The application of somatic cell gene therapy to large patient populati ons will require the development of safe and practical approaches to t he generation and characterization of genetically manipulated cells. T ranskaryotic implantation is a gene therapy system based on the produc tion of clonal strains of engineered primary and secondary cells, usin g nonviral methods. We demonstrate here that, on implantation, these c lonal cell strains stably and reproducibly deliver pharmacologic quant ities of protein for the lifetime of the experimental animals.