THE ASYMPTOTE OF MEASURED CONCENTRATION-T IME CURVES

The measured concentration time curve of an injected substance is ofte n used as a basis for calculating the distribution volume. For the fir st time, the present paper describes a generally applicable formula fo r calculating the asymptote of a concentration time curve in medical a pplications. With a knowledge of this formula, previously unexplained phenomena (varying results obtained from two different methods of calc ulating the distribution volume) can now be understood. At the same ti me, errors of methodology (choice of injection and measuring sites) ca n be avoided.