A MEMBER OF THE FRIZZLED PROTEIN FAMILY MEDIATING AXIS INDUCTION BY WNT-5A

Authors
HE X SAINTJEANNET JP WANG YS NATHANS J DAWID I VARMUS H
Citation
X. He et al., A MEMBER OF THE FRIZZLED PROTEIN FAMILY MEDIATING AXIS INDUCTION BY WNT-5A, Science, 275(5306), 1997, pp. 1652-1654
Citations number
29
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
275
Issue
5306
Year of publication
1997
Pages
1652 - 1654
Database
ISI
SICI code
0036-8075(1997)275:5306<1652:AMOTFP>2.0.ZU;2-I
Abstract
In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecule s induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathway s or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in th e presence of hFz5, a member of the Frizzled family of seven-transmemb rane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synt hase kinase-3 and by the amino-terminal ectodomain of hFz5. These resu lts identify hFz5 as a receptor for Wnt-5A.