MAJOR ANTIGENS OF CRYPTOSPORIDIUM-PARVUM RECOGNIZED BY SERUM ANTIBODIES FROM DIFFERENT INFECTED ANIMAL SPECIES AND MAN

Authors
REPERANT JM NACIRI M IOCHMANN S TILLEY M BOUT DT
Citation
Jm. Reperant et al., MAJOR ANTIGENS OF CRYPTOSPORIDIUM-PARVUM RECOGNIZED BY SERUM ANTIBODIES FROM DIFFERENT INFECTED ANIMAL SPECIES AND MAN, Veterinary parasitology, 55(1-2), 1994, pp. 1-13
Citations number
28
Categorie Soggetti
Parasitiology,"Veterinary Sciences
Journal title
Veterinary parasitology → ACNP
ISSN journal
03044017
Volume
55
Issue
1-2
Year of publication
1994
Pages
1 - 13
Database
ISI
SICI code
0304-4017(1994)55:1-2<1:MAOCRB>2.0.ZU;2-2
Abstract
Serum humoral immune response to Cryptosporidium parvum was evaluated in six species: mouse, rabbit, lamb, calf, pig and man. Electrophoreti c and immunoblot analysis showed that specific animal antibody respons e appeared between Day 4 and Day 15 post inoculation. The two main tar get antigens had apparent molecular weights of 15-17 and 23 kDa. They were recognised by each species studied. Serum IgA intensively recogni sed the 15-17 kDa antigen, except in rabbit. This study demonstrates t hat these two antigens are consistent targets of humoral immune respon se and can therefore be of great interest in studies of therapy/prophy laxis.