The purpose of this paper is the presentation of a general formula for
the asymptotic variance of a semiparametric estimator. A particularly
important feature of this formula is a way of accounting for the pres
ence of nonparametric estimates of nuisance functions. The general for
m of an adjustment factor for nonparametric estimates is derived and a
nalyzed. The usefulness of the formula is illustrated by deriving prop
ositions on invariance of the limiting distribution with respect to th
e nonparametric estimator, conditions for nonparametric estimation to
have no effect on the asymptotic distribution, and the form of a corre
ction term for the presence of nonparametric projection and density es
timators. Examples discussed are quasi-maximum likelihood estimation o
f index models, panel probit with semiparametric individual effects, a
verage derivatives, and inverse density weighted least squares. The pa
per also develops a set of regularity conditions for the validity of t
he asymptotic variance formula. Primitive regularity conditions are de
rived for square-rootn-consistency and asymptotic normality for functi
ons of series estimators of projections. Specific examples are polynom
ial estimators of average derivative and semiparametric panel probit m
odels.