HALOGENATED ISONIAZID DERIVATIVES .2. UNUSUAL SYNTHESIS OF DELTA(2)-1,3,4-OXADIAZOLINE DERIVATIVES FROM ISONICOTINOYLHYDRAZONES AND DIAZOMETHANE

Authors
OTTANA R ROTONDO E VIGORITA MG ZAPPALA C GIORDANO G
Citation
R. Ottana et al., HALOGENATED ISONIAZID DERIVATIVES .2. UNUSUAL SYNTHESIS OF DELTA(2)-1,3,4-OXADIAZOLINE DERIVATIVES FROM ISONICOTINOYLHYDRAZONES AND DIAZOMETHANE, Heterocycles, 38(11), 1994, pp. 2389-2399
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
38
Issue
11
Year of publication
1994
Pages
2389 - 2399
Database
ISI
SICI code
0385-5414(1994)38:11<2389:HID.US>2.0.ZU;2-V
Abstract
The synthesis of a representative group of isoniazid derivatives, name ly aryl-4-methyl-2-pyridyl-DELTA2-1,3,4-oxadiazolines (3) and 4-aryl-1 -methoxy-l-pyridyl-2,3-diazabutandienes (2) by reaction of isonicotino ylhydrazones (1) with diazomethane is described. A mechanism for the u nexpected formation of 3 is suggested.