SYNTHESIS OF MINO-7,8,9,10-TETRAHYDROPYRIDO[3,2-F]-QUINAZOLINES - INHIBITORS OF CANDIDA-ALBICANS DIHYDROFOLATE-REDUCTASE AS POTENTIAL ANTIFUNGAL AGENTS

Authors
CHAN JH HONG JS KUYPER LF JONES ML BACCANARI DP TANSIK RL BOYTOS CM RUDOLPH SK BROWN AD
Citation
Jh. Chan et al., SYNTHESIS OF MINO-7,8,9,10-TETRAHYDROPYRIDO[3,2-F]-QUINAZOLINES - INHIBITORS OF CANDIDA-ALBICANS DIHYDROFOLATE-REDUCTASE AS POTENTIAL ANTIFUNGAL AGENTS, Journal of heterocyclic chemistry, 34(1), 1997, pp. 145-151
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
1
Year of publication
1997
Pages
145 - 151
Database
ISI
SICI code
0022-152X(1997)34:1<145:SOM-I>2.0.ZU;2-U
Abstract
A series of novel amino-7,8,9,10-tetrahydropyrido[3,2-f]quinazolines w ere synthesized starting from 6-amino-5-cyanoquinoline (4). These comp ounds inhibited Candida albicans dihydrofolate reductase with K-i valu es of less than or equal to 0.60 nM. One analogue exhibited moderate i n vivo efficacy in a C. albicans-infected mouse model.