SYNTHESIS OF 2-SUBSTITUTED 4-QUINAZOLONE-5-CARBOXYLIC ACIDS AS INHIBITORS OF DNA-GYRASE

Authors
SUI ZH NGUYEN VN FERNANDEZ J BARRETT JF OHEMENG KA
Citation
Zh. Sui et al., SYNTHESIS OF 2-SUBSTITUTED 4-QUINAZOLONE-5-CARBOXYLIC ACIDS AS INHIBITORS OF DNA-GYRASE, Journal of heterocyclic chemistry, 34(1), 1997, pp. 153-156
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
1
Year of publication
1997
Pages
153 - 156
Database
ISI
SICI code
0022-152X(1997)34:1<153:SO24AA>2.0.ZU;2-O
Abstract
A series of 4-quinazolone-5-carboxylic acids were designed as bacteria l DNA gyrase inhibitors. The syntheses of the target compounds were ac complished by reacting 3-aminophthalimide with aroyl chlorides followe d by rearrangement of the resulting 3-acylaminophthalimides under basi c conditions. The designed compounds showed moderate DNA gyrase inhibi tory activity.