MAGNESIUM CONTENTS OF LEUKEMIC LYMPHOCYTES

In this study, magnesium concentrations were measured in lymphocytes f rom patients with acute myeloblastic leukemia (AML), chronic megalosit er leukemia (KML) and acute lymphoblastic leukemia (ALL) before and af ter chemotherapy management, and results were compared with those of c ontrol subjects. Magnesium concentrations were higher in the patient g roups compared with control values. However, no meaningful differences were found among magnesium concentrations of the patient groups thems elves. Similarly, no statistically meaningful differences were found b etween lymphocyte magnesium concentrations before and after chemothera py management in the patient groups. In the inter-correlation analysis , we observed no correlations between pre- and post-magnesium concentr ations in patients' lymphocytes. It has been suggested that magnesium concentrations of leukemic lymphocytes might increase due to the high ATP requirement of the leukemic cells since magnesium is known to play an important part as a cofactor in most of the energy-producing react ions.