FUNCTIONALIZATION AND CYCLIZATION REACTIONS OF 4-BENZOYL-1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID

Authors
AKCAMUR Y SENER A IPEKOGLU AM KOLLENZ G
Citation
Y. Akcamur et al., FUNCTIONALIZATION AND CYCLIZATION REACTIONS OF 4-BENZOYL-1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID, Journal of heterocyclic chemistry, 34(1), 1997, pp. 221-224
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
1
Year of publication
1997
Pages
221 - 224
Database
ISI
SICI code
0022-152X(1997)34:1<221:FACRO4>2.0.ZU;2-E
Abstract
The 1H-pyrazole-3-carboxylic acid 2 or its remarkably stable acid chlo ride 3 can easily be converted into the corresponding ester or amide d erivatives 4 or 5, respectively, from reaction with alcohols or N-nucl eophiles. Pyrazolo[3,4-d]pyridazines 6a,b are obtained from cycloconde nsation reactions of the pyrazoles 3 and 3, respectively, with phenylh ydrazine or hydrazine hydrate, while 6c is formed in an one-pot proced ure from the furan-a,3-dione 1 and hydrazine hydrate.