NORMAL CAG REPEAT LENGTH IN THE HUNTINGTONS-DISEASE GENE IN SENILE CHOREA

There is a widely held belief that most patients presenting with senil e chorea have late-onset Huntington's disease (HD) with an unknown fam ily history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea an d found that CAG repetition lengths were normal. These findings suppor t senile chorea as being a distinct clinical entity that is nosologica lly separate from late-onset HD.