Ac. Jung et Ds. Paauw, MANAGEMENT OF ADVERSE REACTIONS TO TRIMETHOPRIM-SULFAMETHOXAZOLE IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS, Archives of internal medicine, 154(21), 1994, pp. 2402-2406
Trimethoprim-sulfamethoxazole is an important medication for the treat
ment and prevention of Pneumocystis carinii pneumonia in patients with
the acquired immunodeficiency syndrome. Use of this medication has be
en limited by the high frequency of adverse reactions that occur in pa
tients with human immunodeficiency virus disease. This article reviews
the incidence and spectrum of adverse reactions and options for conti
nuing therapy with trimethoprim-sulfamethoxazole in human immunodefici
ency virus-infected patients who have adverse reactions.