THE COMPLETE H-1 AND C-13 CHEMICAL-SHIFT ASSIGNMENTS OF A CYCLOPROPYLPYRROLOINDOLE ANALOG - ADOZELESIN

The H-1 and C-13 nmr spectral assignments of ylcarbonyl]-1H-indol-5-yl ]-2-benzofurancarboxamide (Adozelesin) (1) are described. Complete and unambiguous assignments of the hydrogen and carbon spectra were made using a combination of conventional homonuclear and gradient-selected inverse-detected heteronuclear nmr experiments: double quantum filtere d H-1-H-1 correlation spectroscopy (COSY), gradient-selected heteronuc lear single quantum coherence spectroscopy (gs-HSQC), and gradient-sel ected heteronuclear multiple bond coherence spectroscopy (gs-HMBC). Th e enhanced sensitivity of these experiments allowed a smaller sample c oncentration and shorter spectral collection times for a full nmr anal ysis of this compound. The nmr data corroborates the published structu re of this compound.