AN EXPEDIENT SYNTHESIS OF (+ -AMINO-3(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID HYDROBROMIDE VIA A 3-BROMOISOXAZOLE INTERMEDIATE/

Authors
HANSON RN MOHAMED FA
Citation
Rn. Hanson et Fa. Mohamed, AN EXPEDIENT SYNTHESIS OF (+ -AMINO-3(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID HYDROBROMIDE VIA A 3-BROMOISOXAZOLE INTERMEDIATE/, Journal of heterocyclic chemistry, 34(1), 1997, pp. 345-348
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
1
Year of publication
1997
Pages
345 - 348
Database
ISI
SICI code
0022-152X(1997)34:1<345:AESO(->2.0.ZU;2-T
Abstract
The excitatory, amino acid amino-3-(3-hydroxy-5-methylisoxazol-4-yl)pr opionic acid hydrobromide was prepared in gram quantities in an 3.3% o verall yield from methylbut 2-ynoate. The key step was the facile prep aration of methyl 3-bromo-5-methylisoxazole-4-carboxylate.