SYNTHESIS AND COMPARATIVE-ANALYSIS OF ANT IGENIC ACTIVITY OF PEPTIDESCORRESPONDING TO VARIOUS GENOMIC SEQUENCES OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 SURFACE GLYCOPROTEIN HYPERVARIABLE-V3 DOMAIN

Authors
SEMILETOV YA RZHANINOVA AA GARAEV MM
Citation
Ya. Semiletov et al., SYNTHESIS AND COMPARATIVE-ANALYSIS OF ANT IGENIC ACTIVITY OF PEPTIDESCORRESPONDING TO VARIOUS GENOMIC SEQUENCES OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 SURFACE GLYCOPROTEIN HYPERVARIABLE-V3 DOMAIN, Bioorganiceskaa himia, 20(10), 1994, pp. 1070-1079
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
20
Issue
10
Year of publication
1994
Pages
1070 - 1079
Database
ISI
SICI code
0132-3423(1994)20:10<1070:SACOAI>2.0.ZU;2-2
Abstract
A set of peptides (amino acid positions 10-23) corresponding to seven most widely spread variants of the gp120 V3 domain in the HIV-infected population of South Russia were prepared by the solid-phase synthesis . A laboratory variant of the indirect enzyme-linked immunosorbent ass ay (ELISA) was developed for the determination of V3 specific antibodi es with use of the peptides synthesized. The analysis of the V3-specif ic antibodies in HIV-infected using the elaborated test-system reveale d a correlation between the V3 variants distribution and the occurrenc e of antibodies against these variants.