Background: Various kinds of viral warts have their own typical clinic
al appearances and histologic properties. From each of them, a corresp
onding unique type of human papillomavirus (HPV) has been detected. Mo
re than 60 types of HPV have been identified from the warts and other
squamous cell epithelial tumors. Human papillomavirus type 60 has been
identified in an epidermal cyst on the sole. We present a case of a p
eculiar plantar wart infected with HPV type 60. Observations: A 21-yea
r-old male student complained of yellowish hyperkeratotic slightly ele
vated nodules on the right plantar arch. The surface of the nodules wa
s not Papillary, but a normal ridge pattern of the sole could be trace
d. Histologic findings included moderate acanthosis, papillomatosis, a
nd eosinophilic intracytoplasmic large granules with or without surrou
nded vacuoles. These were noted in the middle and upper epidermis, inc
luding the hypertrophic stratum corneum. Virologic findings included H
PV antigen detected by anti-HPV polyclonal anitibody. The DNA of HPV t
ype 60 was detected by in situ hybridization. Conclusion: A new type o
f plantar wart infected with HPV type 60 is reported. It shows unique
clinical and histologic findings that can be distinguished from those
of ordinary verruca or myrmecia on the sole.