THE AMINO-ACID-SEQUENCES OF 2 POSTSYNAPTIC NEUROTOXINS ISOLATED FROM MALAYAN COBRA (NAJA-NAJA-SPUTATRIX) VENOM

Authors
CHUNG MCM TAN NH ARMUGAM A
Citation
Mcm. Chung et al., THE AMINO-ACID-SEQUENCES OF 2 POSTSYNAPTIC NEUROTOXINS ISOLATED FROM MALAYAN COBRA (NAJA-NAJA-SPUTATRIX) VENOM, Toxicon, 32(11), 1994, pp. 1471-1474
Citations number
12
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
32
Issue
11
Year of publication
1994
Pages
1471 - 1474
Database
ISI
SICI code
0041-0101(1994)32:11<1471:TAO2PN>2.0.ZU;2-0
Abstract
The complete amino acid sequences of two postsynaptic neurotoxins (tox in-3 and toxin-5) isolated from Malayan cobra (Naja naja sputatrix) ve nom were determined by direct automated Edman degradation of peptides obtained from digests with various proteases. Toxin-3 and toxin-5 are both short-chain neurotoxins and their amino acid sequences are highly homologous to Naja naja atra and Naja naja philippinensis neurotoxin, respectively. Toxin-3 is unique in possessing aspartic acid (D) as th e fifth residue, while all other homologous short-chain neurotoxins ha ve asparagine (N) at the corresponding position.