P170 GLYCOPROTEIN EXPRESSION - A POSSIBLE PROGNOSTIC FACTOR FOR RENAL-CELL CARCINOMA

Authors
BRKOVIC D POMER S STAEHLER G VOLM M
Citation
D. Brkovic et al., P170 GLYCOPROTEIN EXPRESSION - A POSSIBLE PROGNOSTIC FACTOR FOR RENAL-CELL CARCINOMA, Tumordiagnostik & Therapie, 15(5), 1994, pp. 168-170
Citations number
21
Categorie Soggetti
Oncology
Journal title
Tumordiagnostik & Therapie → ACNP
ISSN journal
0722219X
Volume
15
Issue
5
Year of publication
1994
Pages
168 - 170
Database
ISI
SICI code
0722-219X(1994)15:5<168:PGE-AP>2.0.ZU;2-7
Abstract
In a prospective study the expression of P170 glycoprotein was examine d in 28 renal cell carcinomas using the monoclonal antibodies C219 and 265/F4. The correlation to clinical parameters revealed, independent of other prognostic factors like TNM-classification or tumor grade, a shortened survival and time to progression for patients with P170 glyc oprotein negative carcinomas. Therefore, the postoperative immunohisto chemical analysis of the P170 glycoprotein may offer an useful tool to identify patients with poor prognosis and furthermore give implicatio ns for the use of a chemotherapy in case of P170 negative carcinomas.