INTRACORONARY ACETYLCHOLINE-INDUCED PROLONGATION OF THE QT INTERVAL AND TORSADE-DE-POINTES IN LONG QT INTERVAL SYNDROME

Authors
AIZAWA Y MATSUBARA T HIGUCHI K WASHIZUKA T TAMURA Y UCHIYAMA H IGARASHI Y SHIBATA A
Citation
Y. Aizawa et al., INTRACORONARY ACETYLCHOLINE-INDUCED PROLONGATION OF THE QT INTERVAL AND TORSADE-DE-POINTES IN LONG QT INTERVAL SYNDROME, Japanese Heart Journal, 35(5), 1994, pp. 683-688
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Japanese Heart Journal → ACNP
ISSN journal
00214868
Volume
35
Issue
5
Year of publication
1994
Pages
683 - 688
Database
ISI
SICI code
0021-4868(1994)35:5<683:IAPOTQ>2.0.ZU;2-V
Abstract
A 75-year-old female had syncopal episodes from Torsade des Pointes (T dP). Her electrocardiogram showed a prolonged QT interval which was no t associated with electrolyte imbalances or drug therapy. Similar elec trocardiographic abnormalities were found in three family members. Ele ctrophysiologic study showed a mildly prolonged effective refractory p eriod of 260-290 msec, but no tachyarrhythmia was induced. Coronary ar teriography was normal but intracoronary acetylcholine unexpectedly in duced a prolongation of the QT interval and TdP. Direct action of acet ylcholine on the ventricular muscle was suggested.