LIPASE-CATALYZED SYNTHESIS OF OPTICALLY-ACTIVE N,N,N,-TRIMETHYLETHANAMINIUM, ALPHA-TOCOPHEROL ANALOG MDL-73404

Authors
MIZUGUCHI E SUZUKI T ACHIWA K
Citation
E. Mizuguchi et al., LIPASE-CATALYZED SYNTHESIS OF OPTICALLY-ACTIVE N,N,N,-TRIMETHYLETHANAMINIUM, ALPHA-TOCOPHEROL ANALOG MDL-73404, Synlett, (11), 1994, pp. 929-930
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
11
Year of publication
1994
Pages
929 - 930
Database
ISI
SICI code
0936-5214(1994):11<929:LSOON>2.0.ZU;2-V
Abstract
Optically active ,5,7,8,-heptamethyl-2H-1-benzopyran-2-ethanaminium 4- methylbenzene-sulfonate MDL-73404 was synthesized by kinetic resolutio n of racemic chromanethanols with lipase. The unnecessary (R)-chromane thanol as by-product of resolution was inverted to the (S)-isomer that could be treated as substrate for repeated lipase-catalyzed resolutio n.