SYNTHESIS OF ALPHA-[H-2]-AMINES VIA PHOTODECARBOXYLATION OF N-PHTHALOYL ALPHA-AMINO-ACIDS

Authors
GRIESBECK AG HENZ A
Citation
Ag. Griesbeck et A. Henz, SYNTHESIS OF ALPHA-[H-2]-AMINES VIA PHOTODECARBOXYLATION OF N-PHTHALOYL ALPHA-AMINO-ACIDS, Synlett, (11), 1994, pp. 931-932
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
11
Year of publication
1994
Pages
931 - 932
Database
ISI
SICI code
0936-5214(1994):11<931:SOAVPO>2.0.ZU;2-L
Abstract
N-phthaloyl activated alpha-amino acids can be efficiently decarboxyla ted with deuterium incorporation when irradiated in acetone/deuterium oxide mixtures or by irradiation of predeuterated N-phthaloyl alpha-am ino acids (8 examples). Deprotection (hydrazinolysis) of these compoun ds leads to alpha-[H-2]-amines with 95-99% deuterium content.