RHEUMATOID NODULES LOCATED IN THE PENIS OF A METHOTREXATE-TREATED PATIENT WITH RHEUMATOID-ARTHRITIS

A case is reported in which a patient with a rheumatoid factor-negativ e rheumatoid arthritis developed rheumatoid nodules in the penis durin g treatment with methotrexate. The development of rheumatoid nodules i n seronegative rheumatoid arthritis patients is extremely rare. An acc eleration of rheumatoid nodules in methotrexate-treated reheumatoid ar thritis patients is reported in literature. Regarding the case reporte d here, we propose a causal relationship between methotrexate-treatmen t and the development of rheumatoid nodules in our patient. Methotrexa te should not be the preferential treatment for patients with rheumato id arthritis developing rheumatoid nodules and suffering from vasculit is.