A MATHEMATICAL-MODEL FOR THE REGULATION OF TRYPTOPHAN PROMOTER

Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3beta-indoleacryclic acid (IAA). A m athematical model is proposed for the regulation of the promoter by th e manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a p lateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.