Lh. Abrahamsen et al., THE EFFECTS OF CYTOMEGALOVIRUS-INFECTION ON POLAR LIPIDS AND NEUTRAL LIPIDS IN CULTURED HUMAN-CELLS, Intervirology, 39(4), 1996, pp. 223-229
The effects of infection by the human cytomegaloviruses Ad-169 on the
incorporation of [C-14]acetate into the polar and neutral lipids of hu
man embryonic lung cells and human saphenous vein smooth muscle cells
were compared to [C-14]acetate incorporation in mock-infected control
cells. Cytomegalovirus infection caused a shift in the relative amount
s of polar and neutral lipids, with infected cells having lower amount
s of polar lipids and higher amounts of neutral lipids than mock-infec
ted controls. When neutral lipids were separated into diglyceride (DG)
, cholesterol (C), fatty acid, triglyceride (TG) and cholesterol ester
(CE) components, Ad-169-infected cells had lower levels of incorporat
ion of label into CE, TG, and DG fractions, and higher levels of label
incorporation into C than mock-infected cells.