LIPASE-CATALYZED ENANTIOSELECTIVE TRANSESTERIFICATION OF 5-ACYLOXY-2(5H)-FURANONES

Authors
VANDERDEEN H HOF RP VANOEVEREN A FERINGA BL KELLOGG RM
Citation
H. Vanderdeen et al., LIPASE-CATALYZED ENANTIOSELECTIVE TRANSESTERIFICATION OF 5-ACYLOXY-2(5H)-FURANONES, Tetrahedron letters, 35(45), 1994, pp. 8441-8444
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
45
Year of publication
1994
Pages
8441 - 8444
Database
ISI
SICI code
0040-4039(1994)35:45<8441:LETO5>2.0.ZU;2-5
Abstract
Several lipases catalyse the transesterification of gamma-acyloxyfuran ones in organic solvents with high enantioselectivities. This method h as been used for the kinetic resolution of 5-acetoxy-2(5H)-furanone, 5 -acetoxy-4-methyl-2(5H)-furanone and 5-propionyloxy-2(5H)-furanone, in e.e.'s ranging from 68-98%.