N. Yuki et al., MOLECULAR MIMICRY BETWEEN GQ(1B) GANGLIOSIDE AND LIPOPOLYSACCHARIDES OF CAMPYLOBACTER-JEJUNI ISOLATED FROM PATIENTS WITH FISHERS SYNDROME, Annals of neurology, 36(5), 1994, pp. 791-793
We isolated Campylobacter jejuni from 2 patients with Fisher's syndrom
e subsequent to enteritis. Crude lipopolysaccharide fractions were ext
racted from the bacteria and separated by thin-layer chromatography. M
onoclonal antibodies to GQ(1b) ganglioside (GMR13 and 7F5) reacted wit
h both lipopolysaccharide fractions, indicating that the lipopolysacch
arides bear the GQ(1b) epitope. This is the first report of molecular
mimicry between neural tissue components and the antecedent infectious
agents of Fisher's syndrome.