MOLECULAR MIMICRY BETWEEN GQ(1B) GANGLIOSIDE AND LIPOPOLYSACCHARIDES OF CAMPYLOBACTER-JEJUNI ISOLATED FROM PATIENTS WITH FISHERS SYNDROME

Authors
YUKI N TAKI T TAKAHASHI M SAITO K YOSHINO H TAI T HANDA S MIYATAKE T
Citation
N. Yuki et al., MOLECULAR MIMICRY BETWEEN GQ(1B) GANGLIOSIDE AND LIPOPOLYSACCHARIDES OF CAMPYLOBACTER-JEJUNI ISOLATED FROM PATIENTS WITH FISHERS SYNDROME, Annals of neurology, 36(5), 1994, pp. 791-793
Citations number
15
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
36
Issue
5
Year of publication
1994
Pages
791 - 793
Database
ISI
SICI code
0364-5134(1994)36:5<791:MMBGGA>2.0.ZU;2-8
Abstract
We isolated Campylobacter jejuni from 2 patients with Fisher's syndrom e subsequent to enteritis. Crude lipopolysaccharide fractions were ext racted from the bacteria and separated by thin-layer chromatography. M onoclonal antibodies to GQ(1b) ganglioside (GMR13 and 7F5) reacted wit h both lipopolysaccharide fractions, indicating that the lipopolysacch arides bear the GQ(1b) epitope. This is the first report of molecular mimicry between neural tissue components and the antecedent infectious agents of Fisher's syndrome.