ATHEROSCLEROTIC PLAQUE EVOLUTION IN THE DESCENDING THORACIC AORTA IN FAMILIAL HYPERCHOLESTEROLEMIC PATIENTS - A TRANSESOPHAGEAL ECHO STUDY

We explored the concept that transesophageal echocardiography can be u sed as a tool to detect, characterize, and study prague morphology in the descending thoracic aorta. The pattern of atherosclerotic plaques in the descending thoracic aorta in familial hypercholesterolemic (FH) patients was evaluated. Additionally, evolution of plaque characteris tics as a result of therapy was analyzed. In a randomized prospective protocol, eight FH patients (five men and three women, aged 23 to 65 y ears [mean+/-SD, 42+/-14 years]) receiving standard therapy (n=3; base line low-density lipoprotein [LDL] cholesterol, 222+/-71 mg/dL, mean+/ -SD) or LDL apheresis (n=5; baseline LDL cholesterol, 262+/-51 mg/dL) were studied. Baseline and follow-up (mean, 12 months) transesophageal echocardiographic studies were performed. Measurements obtained were atherosclerotic plaque area (PA), aortic wall area (WA), total arteria l area (TAA), and plaque-to-wall area ratio (PWR). LDL cholesterol dec reased in both groups. The greatest severity of plaque was detected at 30 to 35 cm from the incisors (approximately 15 to 20 cm from the aor tic arch). The smallest plaques were present at the arch and more dist al descending aorta. In the control group, TAA, PA, and PWR did not ch ange significantly (P=NS versus baseline). In the LDL-apheresis group, TAA increased (P<.05 versus baseline), PA decreased in three of five patients (P=NS versus baseline), and PWR fell (P<.05 versus baseline). When represented in absolute percentages, the changes between baselin e and follow-up among the control group were TAA +4%, PA +32%, and PWR +24%; among the LDL apheresis-treated group, they were TAA +38%, PA - 24%, and PWR -46%. These preliminary data suggest that transesophageal echocardiography is a useful tool to study atherosclerosis evolution in the descending thoracic aorta. In this preliminary study, LDL apher esis was associated with greater plaque regression than standard thera py.