Ra. Byrd et al., DEVELOPMENTAL TOXICOLOGY STUDIES OF VANCOMYCIN HYDROCHLORIDE ADMINISTERED INTRAVENOUSLY TO RATS AND RABBITS, Fundamental and applied toxicology, 23(4), 1994, pp. 590-597
Pregnant CD rats were given vancomycin intravenously in doses of 0, 40
, 120, or 200 mg/kg on Gestation Days (GD) 6-15; pregnant New Zealand
white rabbits were given 0, 40, 80, or 120 mg/kg intravenously on GD 6
-18. Cesarean sections were performed on rats and rabbits on GD 20 and
28, respectively. In rats, maternal toxicity was indicated in the 120
- and 200-mg/kg treatment groups by cortical tubular nephrosis. Matern
al body weight gain and food consumption and fetal viability, weight,
and morphology were not adversely affected by vancomycin. Maternal and
developmental no observed adverse effect levels (NOAELs) in the rat w
ere 40 and 200 mg/kg, respectively. In rabbits, maternal toxicity was
indicated by cortical tubular nephrosis in the 80- and 120-mg/kg treat
ment groups; a single death and depression of body weight gain and foo
d consumption occurred in the 120-mg/kg treatment group. Developmental
toxicity was indicated by depression of fetal weight in the 120-mg/kg
treatment group; fetal viability and morphology were not adversely af
fected by vancomycin. Maternal and developmental NOAELs in the rabbit
were 40 and 80 mg/kg, respectively. Based on these data, vancomycin di
d not exhibit selective toxicity toward the developing rat or rabbit c
onceptus. (C) 1994 Society of Toxicology.