HYPOPITUITARISM AND HYPONATREMIA IN A CASE WITH NASOPHARYNGEAL CARCINOMA

We report a case of nasopharyngeal carcinoma (NPC) accompanied by hypo natremia and polyuria which was induced by tumor invasion into the pit uitary gland. Magnetic resonance imaging showed the pituitary gland pu shed upward by NPC. Hypopituitarism due to an intracranial tumor and t he extracellular volume excess due to chemotherapy caused hyponatremia and polyuria. As the intracranial tumor was diminished by chemotherap y and irradiation, pituitary hormones were normalized. In patients wit h T4 NPC, pituitary-adrenocortical function should be endocrinological ly evaluated before treatment.