COMPATIBILITY OF PACLITAXEL INJECTION VEHICLE WITH INTRAVENOUS ADMINISTRATION AND EXTENSION SETS

The compatibility of paclitaxel injection vehicle with a variety of i. v. administration and extension sets was studied in terms of the amoun t of diethylhexyl phthalate (DEHP) leached from the sets. Test solutio ns of paclitaxel injection vehicle corresponding to paclitaxel injecti on 0.3 and 1.2 mg/mL were prepared in polyolefin bags of 5% dextrose i njection. The solutions were delivered in triplicate over 24 hours thr ough 26 models of administration sets and 24 models of extension sets and collected in glass containers. Portions were removed after deliver y and analyzed in duplicate for DEHP concentration by high-performance liquid chromatography. All the extension sets were compatible with pa clitaxel injection vehicle. Most of the administration sets were also compatible. However, two administration sets were incompatible with pa clitaxel vehicle corresponding to either drug concentration, and five sets were incompatible with the vehicle simulating the high (1.2-mg/mL ) concentration. Some of the incompatible sets were labeled as not con taining polyvinyl chloride (PVC). Solutions of paclitaxel vehicle leac hed DEHP from administration sets containing PVC and from some sets la beled as not containing PVC.