A SINGLE INFUSION OF BISPHOSPHONATE AHPRBP IN THE TREATMENT OF PAGETS-DISEASE OF BONE

Objective. To assess the efficacy of single infusion of bisphosphonate AHPrPB (APD) (60 mg) in active Paget's disease of bone. Methods. Twen ty-six patients with symptomatic Paget's disease of bone were treated with a single infusion of APD (60 mg) over 12 h and were assessed for clinical as well as biochemical improvement for a mean period of 2 yea rs. Treatments were repeated if relapse occurred during followup. Resu lts. Bone pain improved in 92% of patients within one month and over 7 6% of patients had no pain at 6 months. Serum alkaline phosphatase fel l to normal level in 78% of patients at 6 months and about 77% at one year. Further treatment with intravenous (iv) APD (60 mg) was given fo r relapse in 7 patients at one year, 13 at 18 months and 2 at 24 month s. Conclusion. Our prospective study demonstrates that 60 mg APD given iv is an effective, simple, safe and less expensive treatment for act ive Paget's disease of bone and this therapy may well be given in a da ycare unit or an outpatient setting.