DEVELOPMENTALLY-REGULATED IN-VITRO PHOSPHORYLATION OF CYTOSKELETAL PROTEINS OF THE CEREBRAL-CORTEX OF NORMAL AND MALNOURISHED RATS

In this investigation we studied developmentally regulated endogenous protein kinase activity in cytoskeletal proteins in the cerebral corte x of rats and the effect of early malnutrition imposed on dams on the pattern of P-32 incorporation into the cytoskeleton of pups. Our resul ts indicated that in vitro incorporation was maximum in 7-day-old pups for both normal and malnourished groups, decreasing with development, and reaching minimum values in adult animals. However, P-32 incorpora tion into NF-M and tubulin was significantly lower in 7-day-old malnou rished pups than in normal pups.