TIME-COURSE OF CYTOTOXIC T-LYMPHOCYTE ACTIVITY AFTER INOCULATION OF HERPES-SIMPLEX VIRUS INTO THE ANTERIOR-CHAMBER OF MICE

The time course of the activity of cytotoxic T lymphocytes (CTL) was s tudied after injecting herpes simplex virus (HSV) into the anterior ch amber of C3H/He mice and compared with that following corneal inoculat ion. CTL activity in cervical lymph nodes was suppressed during the 14 days after the inoculation, while that in the spleen increased 2 days earlier compared with the activity after corneal inoculation. The dif ference between the peaks of CTL activity after inoculation via each r oute was not significant. Thus, CTLs from the spleen appear to play a role in the immune response defending mice against intraocular infecti on by HSV.