S. Salem et al., DOPPLER SONOGRAPHY OF ADNEXAL MASSES - THE PREDICTIVE VALUE OF THE PULSATILITY INDEX IN BENIGN AND MALIGNANT DISEASE, American journal of roentgenology, 163(5), 1994, pp. 1147-1150
OBJECTIVE. The purpose of this study was to determine whether pulsed D
oppler sonography can be used to distinguish between benign and malign
ant adnexal masses on the basis of pulsatility index. SUBJECTS AND MET
HODS. In an 18-month period, all patients in whom an adnexal mass was
detected at sonography had further evaluation of the mass by color and
pulsed Doppler sonography. Ninety-nine patients with 102 masses that
were surgically removed were included in the study. The pulsatility in
dexes were calculated from the reproducible spectral waveforms generat
ed from flow centrally or peripherally within or immediately adjacent
to the mass. Each lesion was categorized on the basis of its gray scal
e morphologic features as typically benign or indeterminate/malignant
in appearance. RESULTS. Of the 102 adnexal masses, 89 were benign and
13 were malignant. In seven of the 89 benign lesions, no flow could be
detected, and these were excluded from analysis. Of the remaining 82
benign lesions, 65 showed pulsatility indexes consistently equal to or
greater than 1.0, and 17 showed pulsatility indexes of less than 1.0.
Ten of the 13 malignant lesions had pulsatility indexes consistently
less than 1.0, and three primary malignant tumors had their lowest pul
satility indexes ranging between 1.1 and 1.8. Sixty-five of the 68 mas
ses with pulsatility indexes equal to or greater than 1.0 were benign,
for a positive predictive value of 96% for benign disease. Ten of the
27 masses with pulsatility indexes of less than 1.0 were malignant, f
or a positive predictive value of 37% for malignant disease. Forty-fiv
e masses were detected in perimenopausal and postmenopausal patients.
In this group, the pulsatility index had a positive predictive value o
f 88% for benign disease and 47% for malignant disease. In this study,
45 of 49 masses that had a typically benign sonographic appearance ha
d pulsatility indexes equal to or greater than 1.0. All 49 masses had
benign histology. In the remaining 46 masses with an indeterminate/mal
ignant sonographic appearance, 20 of 23 with pulsatility indexes equal
to or greater than 1.0 were benign, and 10 of 23 with pulsatility ind
exes of less than 1.0 were malignant. CONCLUSION. Our results show a h
igh positive predictive value of high-impedance flow in benign adnexal
disease and a predominance of low-impedance flow in malignant adnexal
disease. However, the pulsatility indexes showed considerable overlap
between benign and malignant lesions, indicating that Doppler sonogra
phy has severe limitations in the differentiation of benign from malig
nant adnexal disease on the basis of low-impedance flow (pulsatility i
ndex < 1.0).