DRUG-DELIVERY SYSTEMS BASED ON INORGANIC MATERIALS .1. SYNTHESIS AND CHARACTERIZATION OF A ZEOLITE-CYCLOPHOSPHAMIDE SYSTEM

Authors
UGLEA CV ALBU I VATAJANU A CROITORU M ANTONIU S PANAITESCU L OTTENBRITE RM
Citation
Cv. Uglea et al., DRUG-DELIVERY SYSTEMS BASED ON INORGANIC MATERIALS .1. SYNTHESIS AND CHARACTERIZATION OF A ZEOLITE-CYCLOPHOSPHAMIDE SYSTEM, Journal of biomaterials science. Polymer ed., 6(7), 1994, pp. 633-637
Citations number
9
Categorie Soggetti
Engineering, Biomedical","Polymer Sciences","Materials Science, Biomaterials
Journal title
Journal of biomaterials science. Polymer ed. → ACNP
ISSN journal
09205063
Volume
6
Issue
7
Year of publication
1994
Pages
633 - 637
Database
ISI
SICI code
0920-5063(1994)6:7<633:DSBOIM>2.0.ZU;2-R
Abstract
Porous material of the CuX zeolite type has been synthesized and used as support for a classic antitumoral drug-cyclophosphamide (CP). The n ew material obtained represents a physical mixture of the two componen ts. In vivo tests allowed biochemical and anatomopathological evaluati on of antitumoral effects determined by oral administration of the CuX zeolite-CP system. Data obtained show that the intensity of the antit umoral effects of the CuX zeolite-CP system is similar as compared to that achieved by CP. A possible advantage of the CuX zeolite-CP system is the continual maintenance in the blood of a CP concentration rangi ng between 100 and 1000 ng ml(-1) plasma.