There is growing consensus that depression is a major public health pr
oblem causing significant psychosocial morbidity and mortality which s
hould be addressed by casefinding efforts in primary care settings. A
large amount of literature has examined the ability of self-report que
stionnaires to detect depression in medical patients and the results h
ave been encouraging. However, studies of general population and psych
iatric patient samples indicate that depression is frequently comorbid
with other psychiatric disorders, and that psychiatric disorders othe
r than depression are also associated with significant morbidity and m
ortality. Consequently, we believe that psychiatric screening in prima
ry care should be broad based. We administered a newly developed, mult
idimensional questionnaire (the SCREENER), that simultaneously screens
for a range of DSM-III-R psychiatric disorders, to 508 medical outpat
ients attending a VA general medical clinic. Compared with nondepresse
d cases, the depressed patients significantly more often reported all
of the nondepressive symptoms. Nine of the ten nondepressive disorders
screened for by the SCREENER were significantly more frequent in the
depressed group. Most patients who screened positive for depression al
so screened positive for at least one nondepressive disorder. Compared
with patients who only screened positive for depression, those who sc
reened positive for both depression and a nondepressive disorder rated
their physical and emotional health more poorly and made more visits
to the doctor. Compared with patients who did not screen positive for
any disorder, those who only screened positive for a nondepressive dis
order rated their physical and emotional health more poorly, and more
frequently had a history of mental health treatment.